Jean-Michel Gracies je profesorem a přednostou na Oddělení Rééducation Neurolocomotrice v Hôpitaux Universitaires Henri Mondor ve francouzském Créteil, kde iniciuje a vede nové neurorehabilitační programy a klinické výzkumné projekty především na poli spastické parézy, parkinsonských syndromů, tremoru, periferní obrny lícního nervu a dalších extrapyramidových onemocnění. Dr. Gracies je světově uznávaný odborník na poli pohybové neurorehabilitace. Mezi jeho dosud publikované zásadní příspěvky patří design, validace a popularizace Tardieuho škály, kterou později začlenil do konceptu 5-Step Clinical Assessment of Spastic Paresis (Klinické vyšetření spastické parézy v 5 krocích), dále definice fenoménu spastické ko-kontrakce a zhodnocení jejího významu jakožto nejzávažnějšího symptomu spastické parézy, a konečně koncept Dohody o reedukačním tréninku, který nachází využití zejména u pacientů se spastickou parézou, ale také u dalších závažných chronických onemocnění. Dr. Gracies je v současné době mezinárodním koordinátorem studií zkoumajících spasticitu s užitím botulotoxinu. Dr. Gracies přednáší po celém světě o patofyziologii a léčbě spastické parézy, neurorehabilitaci u Parkinsonovy nemoci, terapii třesu s využitím botulotoxinu a posilovacího cvičení a programovacích metodách u hluboké mozkové stimulace (DBS)

 

Vzdělání

2007	PM&R, Neurorehabilitation, CHU Henri Mondor, Créteil Obor: Neurologie a neurorehabilitace, Titul: Prof.
2004 – 2007	United states medical licensing Examination Step 1, 2CK, 2CS, 3
1994	University Paris VI Obor: Neurofyziologie, Titul: PhD.
1993	University Paris VI Obor: Neurologie, Titul: M.D.
1992	Atestace Obor: Neurologie
1989	University Paris VI Obor: Neuroanatomie, Titul: MSc.
1988	Educational Comission for Foreign Medical Graduates Foreign Medical Graduate Examination: Medical Sciences
1984	University Paris VI Obor: Biomatematika a statistika, Titul: MSc.

 

Dosavadní zaměstnání

od 2007	přednosta PM&R, Neurorehabilitation, CHU Henri Mondor, Créteil
2002 – 2007	zástupce ředitele Neurologie, Mount Sinai Medical Center, New York, USA
1999 – 2007	Asistent pro obor neurologie Mount Sinai Medical Center, New York, USA
1993 – 1994	asistent Oddělení Neurorehabilitace, Hôpital La Salpétrière, Paris
1989 – 1994	lektor pro obor neurologie Conférencier d’Internat, Paris
1987 – 1994	Lékař Záchranná služba (S.A.M.U.)
1987 – 1992	Rezidentura Interne des Hôpitaux de Paris

 

Odborná činnost

od 1997	recenzent Brain, Exp Br Res, Stroke, Mov Dis, Muscle Nerve, Clin Neuropharm, J Neural Trans, Arch Phys Med Rehab, Clin Neurophys, Am J Phys Med Rehabil, Journal of Neurol, Neurosurg and Psychiatry
od 1998	člen International Movement Disorders Society Allergan Spasticity Advisory Panel Elan Spasticity
od 1998	lektor Advisory Panel Allergan/Comed Advances in Spasticity
od 1998	lektor Neurotoxin Institute
2003 – 2006	Vítěz Cena Učitel roku, cena pro učitele Excellence, studentská cena Outstanding Clinical Faculty Award (v rámci působení v Mount Sinai School of Medicine)
2001 – 2004	člen redakční rady Journal of Neural Transmission
1995 – 1996	Post-Doc stipendista Fondation Simone et Cino Del Duca
1995 – 1996	Post-Doc stipendista INSERM: “Bourse d’Echanges”
1994	vyznamenaný (summa cum laude) Doktorská dizertace „Propriospinální dráhy u lidí“ na University Paris VI
1993	Výherce (Stříbrná medaile) Diplomová práce „Etiologie a rizikové faktory CMP u mladých jedinců“ na University Paris VI, Všeobecné lékařství
1990	Stipendista v rámci doktorského studia Fondation pour la Recherche Médicale
1989	Stipendista v rámci magisterského studia Fondation pour la Recherche Médicale
1997 – dosud	recenzent Brain, Exp Br Res, Stroke, Mov Dis, Muscle Nerve, Clin Neuropharm, J Neural Trans, Arch Phys Med Rehab, Clin Neurophys, Am J Phys Med Rehabil, Journal of Neurol, Neurosurg and Psychiatry
1998 – dosud	člen International Movement Disorders Society Allergan Spasticity Advisory Panel Elan Spasticity
1998 – dosud	lektor Advisory Panel Allergan/Comed Advances in Spasticity
1998 – dosud	lektor Neurotoxin Institute

 

Významné studijní pobyty a stáže

1995-1996	stáž na Prince of Wales Medical Research Institute, Sydney (prof. Burke)
1997-1999	stáž na oddělení Neurology-Movement Disorders, Mount Sinai Medical Center, New York, USA (prof. Olanow)

 

Publikace (pouze vybrané tituly):

Monografie

Gracies JM, Blondel R, Gault-Colas C, Bayle N. Contrat d’Autorééducation Guidée dans la parésie spastique. De Boeck éditions, ©Association Neurorééducation en Mouvement, 2013.

 

Odborné studie

Amirali A, Mu L, Gracies JM, Simpson DM. Anatomical Localization of Motor Endplate Bands in the Human Biceps Brachii. In: J Clin Neuromusc Dis 2007/9(2):306-312.

Archer J, Gracies JM, Touver E, Crimmins DS, Olgart BS, Milder DG. Bilateral optic disk pallor following unilateral internal carotid occlusion. In: Neurology 1998/50(3):809-811 .

Bayle N, Gracies JM. Management of deforming spastic paresis. In: Selzer at al. (eds.), Textbook of Neural Repair and Rehabilitation, Cambridge University Press, 2013, v tisku.

Bayle N, Gracies JM. The Syndrome of Deforming Spastic Paresis: Pathophysiology, Assessment and Treatment. In: Cerebral Palsy In Infancy: Optimizing Development Of Functional Motor Performance, Roberta B. Shepherd, Ed, Elsevier Health Sciences, 2013, v tisku.

Brashear A, Zafonte R, Corcoran M, Galvez-Jimenez N, Gracies JM, Gordon MF, McAfee A, Ruffing K, Thompson B, Williams M, Lee CH, Turkel C.  Inter- and intrarater reliability of the Ashworth Scale and the Disability Assessment Scale in patients with upper-limb poststroke spasticity. In: Arch Phys Med Rehabil. 2002/83(10):1349-1354.

Burke D, Gracies JM, Mazevet D, Meunier S, Pierrot-Deseilligny E. Convergence of descending and various peripheral inputs onto common propriospinal-like neurones in man. In: J Physiol (Lond) 1992/449:655-671.

Burke D, Gracies JM, Mazevet D, Meunier S, Pierrot-Deseilligny E. Non-monosynaptic transmission of the cortical command for voluntary movement in man. In: J Physiol (Lond) 1994/480:191-202.

Burke D, Gracies JM, Meunier S, Pierrot-Deseilligny E. Changes in presynaptic inhibition of afferents to propriospinal-like neurones in man during voluntary contractions. In: J Physiol (Lond) 1992/449: 673-687.

Cubo E, Gracies JM, Benabou R, Olanow CW, Raman R, Leurgans S, Goetz CG. Early Morning Off-Medication Dyskinesias, Dystonia, and Choreic Subtypes. In: Arch Neurol 2001/58(9):1379-1382.

Dunne JW, Gracies JM, Hayes M, Zeman B, Singer BJ. A prospective, multicentre, randomized, double-blind, placebo-controlled trial of onabotulinumtoxin A to treat plantarflexor/invertor overactivity after stroke. In: Clin Rehabil 2012/26(9):787-797.

El Helou A, Bastuji-Garin S, Paillaud E, Gracies JM, Skalli W, Decq P. Determinants for the Use of Ambulation Aids in a Geriatric Rehabilitation Care Unit: A Retrospective Study. In: J Am Med Dir Assoc. 2012/13(3):279-283.

El Helou A, Gracies JM, Decq P, Skalli W. Estimating foot inertial parameters: A new regression approach. In: Clin Biomech (Bristol, Avon). 2012/27(3):299-305.

Germano IM, Gracies JM, Weisz DJ, Tse W, Koller WC, Olanow CW. Unilateral stimulation of the subthalamic nucleus in Parkinson disease: a double-blind 12-month evaluation study. In: J Neurosurg. 2004/101(1):36-42.

Gracies  JM, Meunier S, Pierrot-Deseilligny E, Simonetta M. Pattern of propriospinal-like excitation to different species of human upper limb motoneurones. In: J Physiol (Lond) 1991/434:151-167.

Gracies JM, Bayle N, Vinti M, Alkandari S, Vu P, Loche CM, Colas C. Five-step clinical assessment in spastic paresis. In: Eur J Phys Rehabil Med. 2010/46(3):411-421.

Gracies JM, Burke K, Clegg NJ, Browne R, Rushing C, Fehlings D, Matthews D, Tilton A, Delgado MR. Reliability of the Tardieu scale for assessing spasticity in children with cerebral palsy. In: Arch Phys Med Rehabil. 2010/91(3):421-428.

Gracies JM, Fitzpatrick R, Wilson L, Burke D, Gandevia SC. Lycra garments designed for patients with upper limb spasticity: mechanical effects in normal subjects. In: Arch Phys Med Rehab 1997/78:1066-1071.

Gracies JM, Lugassy M, Weisz DJ, Vecchio M, Flanagan S, Simpson, DM. Botulinum toxin dilution and endplate targeting in spasticity:  A double-blind controlled study. In: Arch Phys Med Rehab 2009/90:9-16.

Gracies JM, Marosszeky JE, Renton R, Sandanam J, Gandevia SC, Burke D. Short-term effects of dynamic Lycra splints on upper limb in hemiplegic patients. In: Arch Phys Med Rehabil 2000/81:1547-1555.

Gracies JM, Meunier S, Pierrot-Deseilligny E. Evidence for corticospinal excitation of human propriospinal-like neurones. In: J Physiol (Lond) 1994/475:509-518.

Gracies JM, Pierrot-Deseilligny E, Robain G. Evidence for further recruitment of group I fibres with high stimulus intensities when using surface electrodes in man. In: EEG Clin Neurophysiol 1994/93:353-357.

Gracies JM, Simpson DM. Spastic Dystonia. In: Brin MF, C Comella, J Jankovic (eds.), Dystonia: Etiology, Classification, and Treatment. Philadelphia: Lippincott Williams & Wilkins, 2004.

Gracies JM, Tse W, Lugassy M, Frank J. Strategies for Physical Exercise in PD. In: Aminoff, Boller, Schwab (eds.), Parkinson’s disease and related disorders. Handbook of Clin Neurol Series, 3rd ed Vol.84.. Series Ed, W Koller. Elsevier 2007.

Gracies JM. [Neurorehabilitace u parkinsonských syndromů], in: Rev Neurol (Paris). 2010;166(2):196-212 [francouzsky].

Gracies JM. Pathophysiology of Spastic Paresis. Part I. Paresis and Soft Tissue Contracture. In: Muscle Nerve 2005/31(5):535-551.

Gracies JM. Pathophysiology of Spastic Paresis. Part II. The Emergence of Muscle Overactivity. In: Muscle Nerve 2005/31(5):552-571.

Gracies JM. Physiological effects of botulinum toxin in spasticity. In: Mov Dis 2004/19(S8):120-128.

Hälbig TD, Assuras S, Creighton J, Borod JC, Tse W, Frisina PG, Voustianiouk A, Gracies JM, Olanow CW. Differential role of dopamine in emotional attention and memory: Evidence from Parkinson's disease. In: Mov Disord 2011/26(9):1677-1683.

Hälbig TD, Borod JC, Frisina PG, Tse W, Voustianiouk A, Olanow CW, Gracies JM. Emotional processing affects movement speed. In:  J Neural Transm 2011/118(9):1319-1322.

Hälbig TD, Creighton J, Assuras S, Borod JC, Tse W, Gracies JM, Foldi NS, Kaufmann H, Olanow CW, Voustianiouk A. Preserved emotional modulation of motor response time despite psychomotor slowing in young-old adults. In: Int J Neurosci 2011/121(8):430-436.

Hälbig TD, Kopp UA, Wodarz F, Borod JC, Gracies JM, Ebersbach G, Kupsch A. Dopaminergic modulation of emotional memory in Parkinson's disease. In: J Neural Transm. 2008/115(8):1159-1163.

Hutin E, Pradon D, Barbier F, Bussel B, Gracies JM, Roche N. Walking Velocity and Lower Limb Coordination in Hemiparesis. In: Gait Posture 2012/36(2):205-211.

Hutin E, Pradon D, Barbier F, Gracies J-M, Bussel B, Roche N. Lower limb coordination in hemiparetic subjects: impact of botulinum toxin injections into rectus femoris. In: Neurorehabil Neural Repair 2010/24:442-449.

Hutin E, Pradon D, Barbier F, Gracies JM, Bussel B, Roche N. Lower limb coordination in hemiparetic subjects: impact of botulinum toxin injections into rectus femoris. In: Neurorehabil Neural Repair. 2010/24(5):442-449.

Hutin E, Pradon D, Barbier F, Gracies JM, Bussel B, Roche N. Lower limb coordination patterns in hemiparetic gait: factors of knee flexion impairment. In: Clin Biomech (Bristol, Avon) 2011/26(3):304-311.

Kaufmann H, Bhattacharya KF, Voustianiouk A, Gracies JM. Stimulation of the subthalamic nucleus increases heart rate in patients with Parkinson’s disease. In: Neurology 2002/59:1657-1658.

Kiernan MC, Hales JP, Gracies JM, Mogyoros I, Burke D. Paraesthesiae induced by prolonged high frequency stimulation of human cutaneous afferents. In: J Physiol (Lond) 1997/501:461-471.

Kiernan MC, Mogyoros I, Hales JP, Gracies JM, Burke D. Excitability changes in human cutaneous afferents induced by prolonged repetitive axonal activity. In: J Physiol (Lond), 1997/500:255-264.

Mogyoros I, Kiernan M, Gracies JM, Burke D. The effects of stimulus duration on the latency of submaximal nerve volleys. In: Muscle Nerve 1996/19:1354-1356.

Moore ST, MacDougall HG, Gracies J-M, Cohen HS, Ondo WG. Long-term monitoring of gait in Parkinson disease. In: Gait Posture 2007/26(2):200-207.

Moore ST, Macdougall HG, Gracies JM, Ondo WG. Locomotor response to levodopa in fluctuating Parkinson's disease. In: Exp Br Res 2008/184(4):469-478.

Olanow CW, Gracies JM, Goetz CG, Stoessl AJ, Freeman T, Kordower JH, Godbold J, Obeso JA. Clinical pattern and risk factors for dyskinesias following fetal nigral transplantation in Parkinson's disease: A double blind video-based analysis. In: Mov Disord. 2009/24(3):336-343.

Simpson DM, Gracies JM, Graham HK, Miyasaki JM, Naumann M, Russman B, Simpson LL, So Y. Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Assessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. In: Neurology 2008/70(19):1691-1698.

Simpson DM, Gracies JM, Yablon SA, Barbano R, Brashear A. BoNT/TZD Study Team. Botulinum neurotoxin versus tizanidine in upper limb spasticity: a placebo-controlled study. In: J Neurol Neurosurg Psychiatry 2009/80(4):380-385.

Sterio D, Rezai A, Mogilner A, Zonenshayn M, Gracies JM, Kathirithamby K, Beric A. Neurophysiological modulation of the subthalamic nucleus by pallidal stimulation in Parkinson's disease. In: J Neurol Neurosurg Psychiatry 2002/72(3):325-328.

Tse W, Cersosimo MG, Gracies JM, Morgello S, Olanow CW, Koller W.  Movement disorders and AIDS: a review. In: Parkinsonism Relat Disord 2004/10(6):323-334.

Tse W, Frisina PG, Hälbig TD, Gracies JM, Liang L, Tarshish C, Lesser G, Neufeld R, Koller WC, Libow LS. The effects of withdrawal of dopaminergic medication in nursing home patients with advanced parkinsonism. In: J Am Med Dir Assoc 2008/9(9):670-675.

Tse W, Libow LS, Neufeld R, Lesser G, Frank J, Dolan S, Tarshish C, Gracies JM, Olanow CW, Koller WC, Halbig TD. Prevalence of movement disorders in an elderly nursing home population. In: Arch Gerontol Geriatr 2008/46(3):359-366.

Tse W, Liu Y, Barthlen GM, Hälbig TD, Tolgyesi SV, Gracies JM, Olanow CW, Koller WC. Clinical Usefulness Of The Parkinson’s Disease Sleep Scale. In: Parkinsonism Relat Disord. 2005/11(5):317-321.

Vassel P, Karoubi E, Robain G, Perrigot M, Roman F, Coulomb T, Combes T, Gracies JM, Jacquet M. Evaluation prospective de la rééducation périnéale chez 150 personnes âgées incontinentes, vivant en institution. In: Ann Réadapt Méd Phys (Paris) 1989/31.

Vinti M, Costantino, Bayle N, Simpson DM, Weisz DJ, Gracies JM. Spastic cocontraction in Hemiparesis. Effects of Botulinum Toxin. In: Muscle and Nerve 2012/46(6):917-925.

Vinti M, Couillandre A, Hausselle J, Bayle N, Primerano A, Merlo A, Hutin E, Gracies JM. Influence of Effort Intensity and Gastrocnemius Stretch on Co-contraction and Torque Production in the Healthy and Paretic Ankle. In: Clin Neurophysiol 2013/124(3):528-535.

Wilson LR, Gandevia SC, Inglis JT, Gracies JM, Burke D. Muscle spindle activity in the affected upper limb after a unilateral stroke. In: Brain 1999/122: 2079-2088.

Wilson LR, Gracies JM, Burke D, Gandevia SC. Evidence for fusimotor drive in stroke patients based on muscle spindle thixotropy. In: Neurosci Lett 1999/264(1-3):109-112.

Wissel J, Ward AB, Erztgaard P, Bensmail D, Hecht MJ, Lejeune TM, Schnider P, Altavista MC, Cavazza S, Deltombe T, Duarte E, Geurts AC, Gracies JM, Haboubi NH, Juan FJ, Kasch H, Kätterer C, Kirazli Y, Manganotti P, Parman Y, Paternostro-Sluga T, Petropoulou K, Prempeh R, Rousseaux M, Slawek J, Tieranta N. European consensus table on the use of botulinum toxin type A in adult spasticity. In: J Rehabil Med. 2009/41(1):13-25.